解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
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卫生保健科学和服务
血液学
免疫学
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泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Staphylococcus aureus is one of the major human pathogens, which causes numerous community-associated and hospital-acquired infections. The regulation of the expression of numerous virulence factors is coordinated by complex interplays between two component systems, transcriptional regulatory proteins, and regulatory ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.20103
更新日期:2012-04-01 00:00:00
abstract::This review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translat...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.19333
更新日期:2012-04-01 00:00:00
abstract::We had previously proposed that the post-transcriptional regulation through microRNA as a mechanism for incomplete penetrance and variable expressivity, leads to lack of correlation between genotype and phenotype. Here we report the validation of miRNA-target interactions we predicted earlier and demonstrate the regul...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.19318
更新日期:2012-03-01 00:00:00
abstract::Nonsense-mediated decay (NMD) is a RNA surveillance pathway that degrades subsets of normal and aberrant mRNAs. Mutations that perturb NMD cause neurological disorders in humans, suggesting that NMD has roles in the brain. Recently, it was shown that NMD is repressed during neural development to allow for the stabiliz...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.9.1.18010
更新日期:2012-01-01 00:00:00
abstract::The GIR1 branching ribozyme constitutes a separate class of naturally occurring ribozymes. Most studies have been performed with the single GIR1 known from the myxomycete Didymium iridis whereas the large number of GIR1s found in the amoeboflagellate Naegleria has remained largely uncharacterized. Here, we investigate...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.6.16027
更新日期:2011-11-01 00:00:00
abstract::By differential high-throughput RNA sequencing (dRNA-seq) we have identified "product RNAs" (pRNAs) as short as 8-12 nucleotides that are synthesized by Bacillus subtilis RNA polymerase (RNAP) in vivo using the regulatory 6S-1 RNA as template. The dRNA-seq data were confirmed by in vitro transcription experiments and ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.5.16151
更新日期:2011-09-01 00:00:00
abstract::Alternative splicing (AS) of pre-messenger RNAs is a major process contributing to both transcriptome and proteome diversity in various physiological and pathological situations. There is also accumulating evidence that various stresses impact on AS. In particular, recent analyses of the transcriptome reveal large num...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.8.5.16016
更新日期:2011-09-01 00:00:00
abstract::Population differences observed for complex traits may be attributed to the combined effect of socioeconomic, environmental, genetic and epigenetic factors. To better understand population differences in complex traits, genome-wide genetic and gene expression differences among ethnic populations have been studied. Her...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.4.16029
更新日期:2011-07-01 00:00:00
abstract::Significant structural and mechanistic similarities between the spliceosomal snRNAs and catalytically critical domains of self-splicing group II introns have led to the hypothesis that the spliceosomes and group II introns may be evolutionarily related. We have previously shown that in vitro-transcribed, protein-free ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.3.15386
更新日期:2011-05-01 00:00:00
abstract::The immaculate annotation of all microRNAs (miRNAs) is a prerequisite to study their biological function on a genome-wide scale. However, the original criteria for proper miRNA annotation seem unsuited for the automated analysis of the immense number of small RNA reads available in next generation sequencing (NGS) dat...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.3.14333
更新日期:2011-05-01 00:00:00
abstract::Earlier we have demonstrated the presence of internal ribosome entry site (IRES) within tumor suppressor p53 mRNA. Here we have mapped the putative secondary structure of p53- IRES RNA using information from chemical probing and nuclease mapping experiments. Additionally, the secondary structure of the IRES element of...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.1.14260
更新日期:2011-01-01 00:00:00
abstract::RNA exosomes are large multi-subunit protein complexes involved in controlled and processive 3' to 5' RNA degradation. Exosomes form large molecular chambers and harbor multiple nuclease sites as well as RNA binding regions. This makes a quantitative kinetic analysis of RNA degradation with reliable parameter and erro...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.1.14067
更新日期:2011-01-01 00:00:00
abstract::RNA editing in flowering plant mitochondria targets several hundred C nucleotides mostly in mRNAs to be altered to U. Several nuclear encoded genes have been recently identified predominantly in Arabidopsis thaliana which code for proteins involved in specific RNA editing events in plastids or mitochondria. These nucl...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.1.14298
更新日期:2011-01-01 00:00:00
abstract::The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic acid structures so that the most thermodynamically stable conformations are formed. This activity is essential for virus replication and has a critical role in mediating highly specific and efficient reverse transcription. NC's fun...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.6.14115
更新日期:2010-11-01 00:00:00
abstract::One of the many important consequences that temperature down-shift has on cells is stabilization of secondary structures of RNAs. This stabilization has wide-spread effects, such as inhibition of expression of several genes due to termination of their transcription and inefficient RNA degradation that adversely affect...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.6.13482
更新日期:2010-11-01 00:00:00
abstract::The ribosome binding site of Escherichia coli rpoS mRNA, encoding the stationary sigma-factor RpoS, is sequestered by an inhibitory stem-loop structure (iss). Translational activation of rpoS mRNA at low temperature and during exponential growth includes Hfq-facilitated duplex formation between rpoS and the small regu...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.6.13768
更新日期:2010-11-01 00:00:00
abstract::Sin Nombre hantavirus (SNV) is a New World hantavirus and causes hantavirus cardiopulmonary syndrome. The viral nucleocapsid protein (N) is an RNA chaperone and has multiple functions important in virus replication. The three negative sense RNA segments of hantaviruses form panhandle structures through imperfect hydro...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.6.13862
更新日期:2010-11-01 00:00:00
abstract::Differential mRNA stability is an important mechanism for regulation of virulence factors in Streptococcus pyogenes (group A streptococcus, GAS), a serious and prevalent human pathogen. We have described 2 Classes of mRNA in GAS that are distinguishable by 1) stability in the stationary phase of growth, 2) kinetics of...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.5.13097
更新日期:2010-09-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the epigenome[1, 2]. These long, polyadenylated RNAs do not code for proteins, but function directly as RNAs, recruiting chromatin modifiers to mediate transcriptional changes in processes ranging from X-inactivation (XIST) to imprint...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.5.13216
更新日期:2010-09-01 00:00:00
abstract::While disruption of alternative splicing underlies many diseases, modulation of splicing using antisense oligonucleotides (AONs) can have therapeutic implications. The most notable example is Duchenne muscular dystrophy (DMD), where antisense-mediated exon skipping can restore the open reading frame and allow the synt...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.4.12264
更新日期:2010-07-01 00:00:00
abstract::The RNase II family of enzymes is ubiquitous and has crucial roles in the processing, degradation and quality control of all types of RNA. These exoribonucleases processively degrade RNA from the 3'-end releasing 5'-nucleotide monophosphates. In prokaryotes, RNase II and RNase R have two N-terminal CSD and one C-termi...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.3.11490
更新日期:2010-05-01 00:00:00
abstract::The synthesis of RNA is highly regulated at all stages by transcription factors. As an essential transcription elongation factor, NusA has been studied biochemically for more than 30 years. However, until now no structural information has been available on NusA-RNAP complexes and the NusA interaction site on RNAP was ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.3.12021
更新日期:2010-05-01 00:00:00
abstract::A very conserved pseudoknot structure has been shown to fold in influenza virus RNA. The pseudoknot encompasses the 3' splice site of segment 8 RNA in both influenza A and B viruses. By sequence comparison of influenza virus strains, we derive a consensus motif that defines a novel RNA pseudoknot family. The orientati...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.2.11287
更新日期:2010-03-01 00:00:00
abstract::Nuclear export of mRNA is a critical event in mRNA biogenesis. Passage of mature messenger ribonucleoproteins (mRNPs) through nuclear pore complexes (NPCs) is facilitated by the Mex67/Mtr2 heterodimer. At the NPC cytoplasmic face, the DEAD-box RNA helicase Dbp5 remodels mRNPs by removing Mex67/Mtr2. This remodeling pr...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.1.10576
更新日期:2010-01-01 00:00:00
abstract::Telomeres, protective nucleoprotein structures located at the ends of eukaryotic chromosomes and until recently regarded as transcriptionally silent, are now known to be transcribed into non-coding RNA molecules called TERRA. The function(s) of TERRA in telomere metabolism is now the subject of intense study given the...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.1.10257
更新日期:2010-01-01 00:00:00
abstract::Riboswitches are cis-encoded, cis-acting RNA elements that directly sense a physiological signal. Signal response results in a change in RNA structure that impacts gene expression. Elements of this type play an important role in bacteria, where they regulate a variety of fundamental cellular pathways. Riboswitch-media...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.1.10757
更新日期:2010-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of naturally occurring, small, non-coding RNAs that control gene expression during development,normal cell function and disease. Although there is emerging evidence that some miRNAs can function as oncogenes or tumor suppressors, there is limited understanding of the role of miRNAs in ca...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.6.5.10079
更新日期:2009-11-01 00:00:00
abstract::The signal recognition particle (SRP) is a ribonucleoprotein complex which participates in the targeting of protein to cellular membranes. The RNA component of the SRP has been found in all domains of life, but the size of the molecule and the number of RNA secondary structure elements vary considerably between the di...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.6.5.9753
更新日期:2009-11-01 00:00:00
abstract::MicroRNAs are small, non-coding RNAs that are increasingly appreciated to play critical roles in the modulation of gene expression. In mammalian cells, our knowledge regarding the full impact of microRNAs on cellular behavior remains fragmentary. This has been due, in significant part, to the limited availability of e...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.5.10081
更新日期:2009-11-01 00:00:00
abstract::Ribonuclease P (RNase P) is a ribonucleoprotein comprised of a catalytic RNA subunit and one or several protein subunits. RNase P is best known for its role in 5'-processing of tRNA precursors. RNase P enzymes from almost all forms of life, including protein-synthesizing organelles, contain an RNase P with a conserved...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.4.9241
更新日期:2009-09-01 00:00:00
abstract::In metazoan organisms, alternative splicing is a central mechanism for the regulation of gene expression. However, many questions remain about the underlying molecular mechanisms. Our recent work suggests that U1 snRNP-independent premRNA splicing occurs in humans, which contributes to the regulation of alternative sp...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.4.9318
更新日期:2009-09-01 00:00:00
abstract::tmRNA employs both tRNA-like and mRNA-like properties as it rescues stalled bacterial ribosomes, while targeting the defective mRNA and incomplete nascent protein for degradation. We describe variation of the tmRNA gene (ssrA) and how it informs tmRNA structure and function. Endosymbiont tmRNAs tend to lose secondary ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.6.4.9172
更新日期:2009-09-01 00:00:00
abstract::The endoribonuclease RNase-L requires 2',5'-linked oligoadenylates for activation, and mediates antiviral and antiproliferative activities. We previously determined that RNase-L activation induces senescence; to determine potential mechanisms underlying this activity, we used microarrays to identify RNase-L-regulated ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.6.3.8526
更新日期:2009-07-01 00:00:00
abstract::The chromatoid body is a large perinuclear ribonucleoprotein particle of germ cells. The chromatoid body is also present in stem cells from planarians. This particle shares markers specific to protein aggresomes and P-bodies, and concentrate several RNA pathways. The assembly mechanism of chromatoid bodies is unknown,...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.2.8049
更新日期:2009-04-01 00:00:00
abstract::Traditionally the principles of protein folding in vivo have been obtained largely from molecular chaperone studies. Through extensive studies on molecular chaperones, it becomes clear that most proteins can fold without their assistance in vivo, suggesting the existence of other chaperone types and mechanisms. Since ...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.1.7441
更新日期:2009-01-01 00:00:00
abstract::Transcriptional regulation of microRNA (miRNA) expression is one of the least understood aspects of miRNA biogenesis. In C. elegans the list of miRNAs whose transcriptional control has been described in some detail is currently limited to four: let-7, lin-4, lsy-6, and mir-61. Each of these genes has been shown experi...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.1.7574
更新日期:2009-01-01 00:00:00
abstract::Eukaryotic gene expression must be coordinated for the proper functioning of biological processes. This coordination can be achieved both at the transcriptional and post-transcriptional levels. In both cases, regulatory sequences placed at either promoter regions or on UTRs function as markers recognized by regulators...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7116
更新日期:2008-10-01 00:00:00
abstract::Seryl-tRNA synthetase (SerRS) catalyzes the ligation of serine to the 3'-end of serine tRNA (tRNA(Ser)), which is typical of the type-2 tRNAs characterized by a long extra arm. The SerRSs are divided into two types, the archaeal/eukaryal and bacterial types. In this study, we solved the crystal structures of the SerRS...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.5.3.6876
更新日期:2008-07-01 00:00:00
abstract::Two different isolates of the myxomycete Didymium iridis harbour homing endonuclease genes that are expressed from group I introns inserted into identical sites within the small subunit ribosomal DNA. The homing endonuclease proteins are related in sequence, and their gene structures share similar features such as the...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.3.4.3958
更新日期:2006-10-01 00:00:00
abstract::In an earlier report two P-transposon insertion alleles of the noncoding hsromega gene, hsromega(05241) and P292 were shown to enhance neurodegeneration caused by expression of ataxin-1 protein with expanded poly-Q in a Drosophila model. In present study, we examined the possible relation between hsromega gene express...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.3.1.2559
更新日期:2006-01-01 00:00:00